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Faculty of Engineering

Thora Bittner NanoelektronikTechnische Fakultät der CAU zu KielKaiserstraße 224143 Kiel, Germany

Thora Bittner

Tel : 0431-880-6076Fax : 0431-880-6077Email: Calvin Klein Thick sole logo espadrilles DjyOPhnB0

Kaiserstraße 2, R.C 004 Phone : Dsquared2 NYLON amp; FAUX LEATHER BOOTS 3vmqtnnuRC
Telefax : +49 431 880-6077 [email protected]

My research interest covers the field of novel electronics devices from device fabrication, thin film analytics to electrical characterization. Examples include the non-linear dynamics of interlayer fluxon (soliton) interactions in stacked superconducting tunnel junctions and the memristive electronic transport in multiferroic tunnel junctions. His main research aims are memristive devices for non-volatile memories and neuromorphic circuits. Especially the experimental realization of time-varying, pulsed-coupled bio-inspired neuronal oscillator networks, comprising signal delay and variable coupling strengths (via memristive devices) attracted his research interest over the last years.

Hermann Kohlstedt is Professor of Nanoelectronics at the Engineering Department of the Christian-Albrechts University (CAU) Kiel, Germany. Prior to this appointment at CAU, he was leading a research group from 1991 to 2009 at the Research Center Jülich, Germany that focused on advanced electronic device concepts and associated materials-processing issues. From 1986 to 1989 he worked at the Institute for Millimeterwave Radiostronomy (IRAM) in Grenoble, France and received his PhD in Physics from the Kassel University in 1989 on superconducting tunnel junctions for heterodyne receivers. From 1990 to 1991 he held a one year appointment at the Advantest Corporation in Sapporo, Japan. In 2000 he received his habilitation in Experimental Physics at the Department of Mathematics and Natural Sciences of Cologne University, Germany.

In 2005/06 Hermann Kohlstedt was on sabbatical at the Materials Science Department of the UC Berkeley and the Advanced Light Source (ALS) at the Lawrence Berkeley National Laboratory, USA with research focus on in-operando soft-Xray spectroscopy of ferroelectric devices. Since 2009 he is working in the field of memristive device for neuromorphic circuits and he is spokes man of the DFG (German Research Society) Research Group FOR2093 entitled: “Memristive Devices for neuronal Systems”. He authored and co-authored more than 170 papers in peer-review journals.

2009 – today: Head of the Chair Nanoelectronics, Institute for Electrical Engineering and Information technology, Technical Faculty, CAU Kiel.

2000 – 2009: Institute for Solid State Research, Research Center Jülich, Development of ferroelectric capacitors ferroelectric field effect transistors and ferroelectric tunnel junctions (FTJs) for non-volatile memory applications, scaling effects in ultrathin epitaxial ferroelectric layers (BaTiO3 und PbZrxTi1-xO3).

2005 – 2006: annual sabbatical at the UC Berkeley (Material Science Department) and Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA, USA, in-situ analytics of ferroelectric capacitors by soft X-ray absorption spectroscopy (SXAS), Installation of a pulsed Laser deposition system (PLD) at an ARPES beam line.

2000 Habilitation at the University of Cologne, Department of Mathematics and Natural Sciences, 2nd Institute of Physics.

1991 – 1999: Institute of Thin Film and Ion Technology (ISI), Research Center Jülich, Germany: First experimental evidences of solitons (flux quanta) in multilayered, superconducting long Josephson tunnel junctions, Research on HTC step-edge junctions for field effect transistor applications, HTc Josphson mixer and hot electron bolometer for heterodyne receivers. Research on magnetic (CoFe/Al2O3/CoFe) tunnel junctions for non-volatile memories.

1990 – 1991: Advantest Laboratories, Sapporo, Japan and University Hokkaido (Depart. of Electr. Eng.) Reearch on HTc superconductors and telegraph noise in tunnel junctions.

1986 – 1989: PhD thesis at the Insitut de Radioastronomie Millimétrique (IRAM, Max- Planck - CNRS), Grenoble, France: Development of superconducting (SIS) quantum mixer (Nb-AlOx-NbAl/AlOx/Nb junctions) for frequencies up to 230 GHz. Application of such junction in a radio astronomy sub-mm-wave telescopes. Post-Doc position in IRAM until March1990.

1980 – 1986: Study of Physics at the TH-Darmstadt and the University of Kassel (Diploma in Physics 1986), Development of an electron beam writing system on the basis of a scan electron microscope.

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To determine whether evolutionary constraint in alternating drugs is associated with negative cross-resistance, we selected, isolated, and profiled 40–44 single-step mutants resistant to each drug used in this study ( Fig. 4 A ). To mirror the evolution experiment conditions as closely as possible when selecting these single-step mutants, we cultured wild-type cells in liquid media with inhibitory concentrations of antibiotic and plated on agar plates to isolate single colonies ( Materials and Methods ). Given the short culture time (20 h), we expect most of these isolates to have acquired only a single mutation. We measured the sensitivity of each single-step mutant to all three drugs, and found that, consistent with previous reports ( Vince Camuto Mens Neff SlipOn Sneaker PG4bF
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40 ), cross-resistance was frequent (69% of all mutants showed cross-resistance to at least one drug) and not always reciprocal. Sampling many mutants per drug revealed variation in cross-resistance, ranging from 2.8-fold resistance to 5.7-fold sensitivity in the same drug ( Fig. 4 B ).

Fig. 4.

Cross-resistance explains efficacy of alternating drug treatments. () Single-step mutants were generated by culturing wild-type cells in liquid media with antibiotic for 20 h, then isolated by pooling wells that grew to turbidity, and then plating these mutants on agar plates with enough antibiotic to prevent growth of the wild-type cells. At least 40 resistant colonies were selected for each drug and then phenotyped in all three drugs ( ). () Cross-resistance of single-step TMP-, NEO-, and CIP-resistant mutants. Histograms show the distribution of resistance level (MIC) to the three drugs relative to the ancestor. The measurements of selected resistance are shown in colors and those of cross-resistance are shown in gray. Dashed lines indicate the mean resistance. Colored arrows indicate significant cross-resistance (mean change in log MIC > 0.25), and colored horizontal bars indicate no significant cross-resistance (mean change in log MIC < 0.25). () Cross-resistance correctly predicts effect of alternating drugs on both component drugs for the TMP-NEO and TMP-CIP drug pairs, and on NEO for the NEO-CIP drug pair (the only inconsistency is effect on CIP in NEO-CIP drug pair). Arrows indicate change in rate of evolution of resistance in alternating drugs compared with single-drug treatment, as observed during evolution experiments ( Kenneth Cole Lyon Drivers MVmY3
) and as predicted by cross-resistance measurements (). Horizontal bars indicate a prediction or observation of no change in rate of evolution of resistance.

Despite this variation, the mean cross-resistance of single-step mutants selected in a drug correlated with whether or not alternating treatments slowed resistance to that drug in the evolution experiments. For example, most TMP-selected mutants showed negative cross-resistance to CIP but not vice versa ( Fig. 4 B ). Correspondingly, populations evolved under alternating TMP-CIP treatment were less resistant to TMP, but not CIP, than those evolved in the respective single-drug treatments. This pattern suggests constraint on the acquisition of TMP-resistance, rather than the accumulation of negative cross-resistance mutations (which would predict slower evolution of resistance to CIP). Similarly, most TMP-selected mutants had negative NEO cross-resistance but NEO-selected mutants had no cross-resistance to the drugs used, as we would expect based on the patterns of resistance among populations evolved under alternating- and single-drug populations. We observe that the absence of cross-resistance for a given set of conditions correlates perfectly with the absence of change in the rate of resistance (three of three cases). Overall, the cross-resistance pattern of single-step mutants correctly predicted the resistance outcome of alternating treatments compared with single-drug treatments in five of six cases (all except CIP cross-resistance in NEO) ( Fig. 4 C ).

I’m going to try to adopt the mentality that by making nice with EVERYONE, I’m being fascinating to NOONE. It’s compromising my core desires and life, and that sucks.

Thanks so much for shining your wisdom, Sally!

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I watched this episode twice in a row it was so intriguing! Trust and Rebellion I think describes me. How do those go together? I’ll have to check out Sally’s book! Thanks for this look at the world from another point of view!

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This episode was – drum roll – f-a-s-c-i-n-a-t-i-n-g! I related to the blog because my articles always have a story and then the information. I recall many years ago throwing out a blog on lessons I learned on life with my sculling. This article was very personal and authentic. The response was amazing so I learned it is best to be my true self!

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Thank you so much Marie, and thank you Sally!

I am The Orchestrator – this definitely comes across when I’m teaching a class or planning a dinner party. Hmm, maybe I should be doing more of both!

I love that I now have a whole report full of tools for leveraging the best of me, to get my UAP more visibly out to the world!

Reply

As always Marie – excellent. These are things I am working with at the moment – especially going through B School. It is these kinds of tools that really help define the path in a way that is not limiting but builds confidence.

I would say that the one trait that has the most trouble is my humor and somewhat creatively goofy/irreverent qualities. I have been told at times that it is why I have not advanced in certain situations – perhaps because I am not serious enough. There is a way in which that at times is seen as not being “adult” or mature enough. However my humor is not to tell a lewd joke but rather to find ways to shift the energy of situation by reminding them that life can hold a broader view. Since part of my work now is working with people at end of life I am taken by how many times people need this kind of interact in times of pain.

I think I utilized this quality of myself more when I was doing theatre and performance regularly, but in the last 13 years this has been pulled back. It is a reason why I feel stuck and not using the strength and quality that could generate more fascination.

So thank you again for the episode.

As always a deep bow of appreciation for encouraging joy and wisdom in the world – Carlyle

Reply

The test/site does freeze, often. I just kept refreshing and it eventually worked. I’m going to download the PDF so I don’t have to keep reloading the site. Maybe all this traffic is slowing it down…

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